Quarterly Journal of Science and Practice
D. V. Merezhkina, A. R. Pluzhnikova, S. Yu. Kozlov, G. N. Solodunova, M. S. Novikov, A. A. Ozerov
Волгоградский государственный медицинский университет, Волгоград, Россия; Волгоградский медицинский научный центр, лаборатория медицинской химии, Волгоград, Россия
A comparative analysis of four different methods of the synthesis of N1-monosubstituted derivatives of quinazoline- 2,4(1 H,3H)-dione was carried out. It has been shown that, depending on the nature of the alkylating agent, the use of quinazoline- 2,4(1 H,3H)-dione or its 1,3-dibenzoyl derivative as a substrate is the most effective during the conducting of reaction in an anhydrous DMF medium in the presence of an excess of potassium carbonate at room temperature.
quinazoline-2,4(1H,3H)-dione, alkylation, regioselectivity
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