Quarterly Journal of Science and Practice
A.A. Tsibizova, M.U. Sergalieva, O.A. Bashkina, M.A. Samotrueva
Астраханский государственный медицинский университет, Астрахань, Россия
Objective - evaluation of the anti-inflammatory activity of the liquid extract of leaves and fruits of Japanese stone loch. Materials and methods. The studies were performed on white nonlinear male rats weighing 210-230 g. The anti-inflammatory activity of the extract was estimated by simulating chronic inflammation by implanting a sterile cotton ball under the back skin of the laboratory animals. The animals were divided into four groups (n=8): Group 1 (control I) - animals receiving an intragastric equivalent volume of distilled water; Group 2 (control II) - animals with a model of chronic inflammation not treated; Group 3 (trial 1) - rats receiving intragastric liquid extract of leaves and fruits of Lochus narrow-leavedis in a dose of 20 mg/kg (in terms of extractive substances - not less than 18%) for 7 days, starting from the day of cotton ball implantation; Group 4 (trial 2) - animals receiving intragastric comparison drug - nimesulide in a dose of 2.5 mg/kg for 7 days, starting from the day of cotton ball implantation. Results. The model of chronic inflammation revealed marked anti-inflammatory activity of the liquid extract of leaves and fruits of Lochus narrow-leaved, which was proved by reduction of leukocyte number, C-reactive protein and IL-6 levels, increase of IL-10 concentration. Conclusions. Thus, our experimental data indicate that the liquid extract of leaves and fruits of Elaeagnus angustifolia growing in the territory of the Astrakhan region has a pronounced antiexudative and antiproliferative effect and may be used as an anti-inflammatory agent after additional studies
Elaeagnus angustifolia, anti-exudative action, antiproliferative action, anti-inflammatory activity
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