Volgograd Journal of Medical Research

Volgograd Journal of Medical Research

Quarterly Journal of Science and Practice


UDK: 576.343:616-002

ROLE OF A2A SUBTYPE ADENOSINE RECEPTORS IN THE INFLAMMATION

Elena A. Muzyko, Valentina N. Perfilova

Волгоградский государственный медицинский университет, Волгоградский медицинский научный центр

Резюме

Adenosine receptors are widely distributed in various organs and tissues of our body, including the nervous and cardiovascular systems. Adenosine receptors activation is associated with both proinflammatory and antiinflamma- tory effects. Modern literature sources indicating the role of adenosine receptors of the A2A subtype in the development of inflammatory processes in nervous and cardiovascular diseases including cerebral ischemia, damage to the blood- brain barrier, encephalomyelitis, ischemic heart disease, atherosclerosis, myocardial infarction, chronic heart disease failure were analyzed in this review.

Ключевые слова

adenosine A2A receptors, inflammation, diseases of the nervous system, cardiovascular diseases

Show full text of article