Quarterly Journal of Science and Practice
Vitaly N. Morozov, Vladislav I. Luzin
Белгородский государственный национальный исследовательский университет, Белгород, Россия; Луганский государственный медицинский университет им. Святителя Луки, Луганск, Россия
Despite the strict regulation of the content of sodium benzoate and tartrazine in products, the question of their safety in relation to human health remains open. Description of what an article is devoted to. The paper describes the dynamics of changes in the organometric and morphometric parameters of the parathyroid glands of rats in response to prolonged administration of sodium benzoate or tartrazine. Materials and methods. The research was carried out on 150 white mature rats divided into 5 groups-control and groups in which animals received sodium benzoate at doses of 500 and 1000 mg/kg or tartrazine at a dose of 750 and 1500 mg/kg for 60 days. Quantification of changes in the parathyroid glands was carried out using the histomorphometric method. Results. The most pronounced amplitude deviations from the data of the control group of the largest and smallest diameters of the parathyroid glands, the number of nuclei of the chief cells per unit area, the average diameter of their nuclei and the index of proliferative activity were established on the days 3 and 10 of the experiment, and their gradual recovery to control values by days 24 and 45. The least pronounced and prolonged changes in quantitative data were observed in the group using sodium benzoate at a concentration of 500 mg/kg, and the greatest in the group with the introduction of tartrazine at a dose of 1 500 mg/kg of body weight. Scientific contribution. Complementing and expanding the available information on the effect of these food additives on the human body and experimental animals. Conclusion. Long-term exposure to sodium benzoate and tartrazine causes a dose-dependent decrease in the functional activity of the chief cells of the rat’s parathyroid glands. Area of application. Nutritionology, experimental endocrinology. Directions of future studies. Confirmation of the obtained data by electron microscopy and nzyme immunoassay.
parathyroid gland, chief cells, sodium benzoate, tartrazine, morphometry
Show full text of article