Quarterly Journal of Science and Practice
Yulia A. Makedonova, Svetlana A. Kalashnikova, Ekaterina S. Aleksandrina, Уапта P. Bolovina
Волгоградский государственный медицинский университет, Волгоград, Россия; Волгоградский медицинский научный центр
Recurrent aphthous stomatitis (RAS) is the third most common in the structure of diseases of the oral mucosa. Over the past 3 years, according to the data of a retrospective analysis, there was an increase in pathology by 1,92 %. The etiology remains de¬batable in the research environment, but, as a rule, the development of RAS is associated with a genetic predisposition, and specifical¬ly with the influence of epigenetics, endocrine diseases, diseases of the gastrointestinal tract, etc. There are a large number of studies in the literature on the relationship between COVID-19 infection and RAS, most likely this could be one of the reasons for the increase in the disease over the past 3 years. Patients, despite ongoing therapy, suffer from excruciating pain when eating and talking. All this dictates the need to search for new means and methods of local treatment of RAS, as well as ways to prevent new relapses. Crystallo¬graphic study is one of the available non-invasive methods to evaluate the effectiveness of the therapy. The aim of the study was to analyze the crystallograms of patients with RAS in the course of treatment with sodium deoxyribonucleate. The results of the analysis of the crystallograms of patients with RAS showed that the group using sodium deoxyribonucleate in local treatment had a clearer or¬dered crystal structure, and the quantitative analysis was significantly different from the group (p < 0.05) where the conventional treat¬ment regimen was used. Conclusion. A crystallographic study made it possible to conduct a comparative analysis and prove the effec-tiveness of prescribing sodium deoxyribonucleate in local therapy for PAS.
aphthous stomatitis, sodium deoxyribonucleate, crystallogram, oral fluid
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