Quarterly Journal of Science and Practice
M. O. Skripka 1, 2 , D. V. Maltsev, M. V. Miroshnikov, L. A. Smirnova, O. K. Abramov, A. F. Ryabukha, A. A. Spasov
Волгоградский государственный медицинский университет, Волгоград, Россия; Волгоградский медицинский научный центр, Волгоград, Россия
In the present study, we studied the effect of a new derivative of C2,C3-quinoxaline with anxiolytic activity, the compound A81, on the concentration of noradrenaline, dopamine, serotonin, 5-hydroxyindoleacetic acid (5-HIAA), and dihydroxyphenylacetic acid (DPAA) in brain tissues. The study was performed using a high performance liquid chroma- tography technique. Based on the study in biological samples under the influence of compound A81, in contrast to diaz- epam, an increase in the concentration of free serotonin with a more significant decrease in the content of dopamine and its metabolite DPAA is characteristic.
HPLC, 5-OIA, DPAA, norepinephrine, serotonin, dopamine, rats, quinoxaline, diazepam, anxiolytic, brain
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