Quarterly Journal of Science and Practice
Kirill A. Miroshnichenko, Maxim V. Chernikov, Anna A. Potapova
Пятигорский медико-фармацевтический институт – филиал Волгоградского государственного медицинского университета, Пятигорск, Россия
This experimental work was carried out to determine the effect of the introduction of a new pyrimidine deriva- tive on neurodegradation in conditions of chronic traumatic encephalopathy on 100 male Wistar rats. To reproduce the pathology, an installation was used that simulates the effects of an explosive wave, exposure to animals was carried out once. Choline alfoscerate and gopantenic acid acted as reference drugs. The comparison preparations and the test compound were administered once 30 min after the pathology simulation. Determination of neurodegradation markers: glial-fibrillar acid protein (GFAP) and beta-amyloid (Aβ) was carried out 1 day and 14 days after modeling pathology us- ing solid-phase enzyme immunoassay. The results obtained indicate the presence of cerebroprotective activity of the new pyrimidine derivative.
chronic traumatic encephalopathy, pyrimidine derivatives
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