Quarterly Journal of Science and Practice
D. S. Mednikov, A. V. Smirnov, I. N. Tyurenkov, D. V. Kurkin, E. V. Volotova, D. A. Bakulin
Волгоградский государственный медицинский университет, кафедра патологической анатомии, кафедра фармакологии и биофармации ФУВ, Волгоград, Россия; Волгоградский медицинский научный центр, лаборатория патоморфологии, Волгоград, Россия
The article demonstrates the result of an immunohistochemical study of the pyramidal layer of the hippocam-pus of rats with simulated stenosis of the common carotid arteries using antibodies against glial fibrillary acidic protein (GFAP). The most significant increase in GFAP expression was found in CA3 of the pyramidal layer of the hippocampus, where the relative area of the immunopositive material significantly increased by 6.6 % (p < 0.001) compared with the control group. In CA2 and CA4, the relative area of the immunopositive material significantly increased by 6.3 % (p < 0.01) and 3.3 % (p < 0.001), respectively. Reactive astrogliosis has adaptive character and provides the formation of a glial scar, as well as trophic support of pyramidal neurons in conditions of chronic ischemia.
hippocampus, rat, carotid stenosis, GFAP
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