Quarterly Journal of Science and Practice
E. R. Garsiya, D. I. Pozdnyakov, A. A. Shamilov, D. A. Konovalov
Пятигорский медико-фармацевтический институт – филиал ВолгГМУ, кафедра фармакогнозии, ботаники и технологии фитопрепаратов, кафедра фармакологии с курсом клинической фармакологии
The paper describes the results of assessing acute toxicity, anti-inflammatory activity on models of acute and chronic inflammation, antioxidant activity of water-alcohol extracts and juice from the herb of Onopordum acanthium L. Extracts and juice can be attributed to the 5th class of chemical hazard according to the GSH classification, there is a pro- nounced anti-inflammatory activity of 40 % of alcohol and water extracts, as well as juice from fresh herb of the Onopordum acanthium (reduction of carrageenan-induced edema of the limb of rats by 33,2 % (p < 0,05); 22,3 % (p < 0,05) and 29,5 % (p < 0,05), respectively). The same objects reduced the severity of exudation phases (by 57,3 % (p < 0,05); 54,3 % (p < 0,05) and 48,9 % (p < 0,05), respectively) and proliferation (by 52,7 % (p < 0,05); 38,7 % (p < 0,05) and 43,8% (p < 0,05), respectively). At the model of modulation of formalin-evoked hyperalgesia water-alcohol extracts (40 % ethanol), water extract and juice were increased pain threshold.
toxicity, anti-inflammatory and activity, Tartarus prickly grass
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