Quarterly Journal of Science and Practice
E. V. Blynskaya, D. V. Yudina, K. V. Alekseyev, V. K. Alekseyev, S. V. Minaev
ФГБНУ «НИИ фармакологии имени В. В. Закусова», Москва
The study investigates the effect of solvent nature on the compression characteristics of wet-granulated tableting mixtures of a new anxiolytic active pharmaceutical ingredient GML-1. Laser diffraction method was used to determine mesh-size distribution of granulated tablet mixtures. Compressibility was determined using the «out-of-die» Heckel (equation 1) and Kawakita models (equation 3).
wet granulation, compressibility, GML-1, Kawakita equation, Heckel equation, mesh-size distribution
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