Quarterly Journal of Science and Practice
G. N. Solodunova, A. O. Volkova, A. S. Korsheninnikova, A. R. Kucherenko, E. D. Skorokhod, V. I. Tolkacheva, K. V. Turchenkova, L. V. Turchenkova
Волгоградский медицинский научный центр, лаборатория медицинской химии
The bromination of methyl anthranilate with N-bromosuccinimide in anhydrous N,N-dimethylformamide leads to 5-bromo- or 3,5-dibromoanthranilic acid methyl ester depending on the amount of brominating agent. Further cyclization of these esters in boiling formamide gives 6-bromoquinazolin-4(3H)-one or 6,8-dibromoquinazolin-4(3H)- one with good (69–83 %) yield.
methyl anthranilate, bromination, N-bromosuccinimide, cyclisation, quinazoline
Show full text of article