Quarterly Journal of Science and Practice
G. N. Solodunova, E. A. Solodunova, A. V. Gerasimenko, V. G. Klochkov, V. L. Klochkova
Волгоградский медицинский научный центр, лаборатория медицинской химии
The alkylation of 6,8-dibromoquinazolin-4(3H)-one with esters of 2-halogencarboxylic acids in anhydrous DMF in the presence of potassium carbonate leads to corresponding esters of 2-[4-oxo-6,8-dibromoquinazolin-3(4H)-yl]carboxylic acid with good (77–82 %) yield.
6,8-dibromoquinazolin-4(3H)-one, bromoacetic acid, 2-chloropropionic acid, N-alkylation
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