Quarterly Journal of Science and Practice
B. E. Tolkachev, A. M. Docenko, A. O. Strygina, O. V. Magnitskaya
Волгоградский государственный медицинский университет, ГБУ Волгоградский медицинский научный центр, лаборатория клинической фармакологии
Development and validation of the highly selective and sensitive LC-MS/MS method to detect valsartan and hydrochlo- rothiazide in human plasma were performed. Mass spectrometriy detection made it possible to enhance analytical per- formance without time- and labor consuming sample preparation procedures, thus improving the overall bioanalytical productivity in the course of the bioequivalence study.
bioanalysis, LC-MS/MS, QTRAP, valsartan, hydrochlorothiazide
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