Quarterly Journal of Science and Practice
E. A. Solodunova, M. S. Novikov, A. A. Ozerov
Волгоградский медицинский научный центр, лаборатория медицинской химии
Unlike the non-methylated analogue, 2-methylquinazolin-4(3H)-one, bromination with elemental bromine takes place at the methyl group and does not affect the heterocyclic aromatic nuclei. 6-bromo-2-methylquinazolin-4(3H)-one was synthesized with a yield of 55% by heating the methyl ester 2-acetylamino-5-bromobenzoic acid with ammonium hydroxide.
quinazoline, bromination, N-bromosuccinimide, cyclisation.
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