Quarterly Journal of Science and Practice
E. G. Glukhova, O. I. Ivanova, G. N. Solodunova
Волгоградский медицинский научный центр, лаборатория медицинской химии
Hydrazone of 3-(2-oxopropyl)quinazolin-4(3H)-on was synthesized by alkylation of quinazolin-4(3H)-on with chloroacetone followed by condensation with hydrazine. The compound enhanced the hypnotic effect of sodium thiopental and reduced the convulsive effect of picrotoxin.
qiunazoline, chloroacetone, alkylation, hydrazone, thiopental, picrotoxin.
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