Quarterly Journal of Science and Practice
N. A. Gurova, A. S. Pitersen, V. Y. Fedorchuk, D. V. Kosolapova
Волгоградский государственный медицинский университет, кафедра фармакологии
It was determined that amiloride inhibited platelet Na+/H+-exchange in dose-dependent manner and IC50 was 1,23 x 10^-6 M/L. Acute toxicity of amiloride was investigated in mice after i. p. administration, and LD50 amounted to 35 mg/kg. Conditional therapeutic index of 106,1 units was calculated.
Na+/H+-exchanger, platelets, amiloride, LD50
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