Quarterly Journal of Science and Practice
I. N. Tyurenkov, V. N. Perfilova, D. D. Borodin
Кафедра фармакологии и биофармации ФУВ ВолгГМУ, Научно-исследовательский институт фармакологии ВолгГМУ
It is shown that occlusion of the left coronary artery descending branch (OLCADB) leads to chronic heart failure (CHF) in animals within 28 days, as it is evidenced by the negative hemodynamic changes and high percentage of myocardium necrosis zones. Mildronate and, lately, mexidole displayed cardio-protective effect in CHF experimental condition limiting hemodynamic changes and myocardium necrotic zone in animals. Trimetazidine proved ineffective when administered in this model of CHF.
occlusion of the left coronary artery descending branch, chronic heart failure, mildronate, mexidole, trimetazidine
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